Biological half-life of prostate-specific antigen after radical prostatectomy.
نویسندگان
چکیده
The disappearance pattern of prostate-specific antigen from serum after a standard radical prostatectomy was studied in eight patients with cancer confined to the prostate. The results were used to plot an elimination curve and calculate the best fit. A biphasic pattern was found with an average biological half-life of 1.63 hours in the alpha-phase, and 4.63 days in the beta-phase. Based on these results it is concluded that determination of prostate-specific antigen concentrations less than one month after a standard radical prostato-vesiculectomy has no value for the detection or exclusion of residual malignant processes.
منابع مشابه
Serum half-life time determination of free and total prostate-specific antigen following radical prostatectomy--a critical assessment.
OBJECTIVES All studies investigating the elimination kinetics of serum total (tPSA) and free (fPSA) prostate-specific antigen (PSA) were carried out in men undergoing radical prostatectomy. Radical prostatectomy itself could, however, have a major influence on the serum concentration of these tumor markers (e.g., perioperative fluid shift or blood loss). The purpose of our study was to determin...
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متن کاملLong-term oncological outcome and risk stratification in men with high-risk prostate cancer treated with radical prostatectomy.
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عنوان ژورنال:
- European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies
دوره 32 2 شماره
صفحات -
تاریخ انتشار 1994